Since the 1990s, Professor Hopf has played a decisive role in the development of endoscope-assisted microsurgery and endoscopic skull-base surgery, and has acquired special expertise in the transcranial and transnasal endoscopic treatment of tumours of the central cranial base (sella region), the brain stem and spinal cord, and the pineal region. From 2005 to 2014, Professor Hopf held a teaching position at the Johannes Gutenberg University (Mainz) and at the Eberhard Karls University in Tübingen.


From 2009 to 2012, Professor Hopf was editor-in-chief of the international journal “Minimally Invasive Neurosurgery” and subsequently of its successor “Innovative Neurosurgery”. Among other things, he has published extensively on the endoscopic treatment of hydrocephalus and arachnoid cysts and on the minimally invasive treatment of complex cerebral vascular diseases such as multiple brain aneurysms. His post-doctoral lecturing qualification paper discussed the migratory activity of brain tumour cells. Professor Hopf’s scientific interest continues to focus on neuro-oncology and the development of new minimally invasive surgical techniques and instruments.


He is an enthusiastic lecturer, who has contributed to more than 60 training courses on endoscopic and minimally invasive and skull-base surgery around the world, also supervising a number of international interns in Stuttgart and Zurich. He is a popular speaker at national and international events and is much in demand among colleagues and patients seeking advice about complex neurosurgical diseases.


Born in 1964 in Würzburg, Germany.
Medical Studies
Medical studies at the Johannes Gutenberg University, Mainz.
Specialist education
Specialist training from Prof. Axel Perneczky in Mainz.
Study mission
Residency with Dr. Kim Manwaring in Pediatric Neurosurgery at Phoenix Childrens Hospital and with Dr. Robert Spetzler for Neurovascular Diseases and Skull Base Surgery at the Barrow Neurological Institute in Phoenix, Arizona/USA.
Senior Physician
Senior Consultant and Deputy Director of the Neurosurgical University Hospital Mainz, 1999. Appointed Professor of Neurosurgery at the Faculty of Medicine at the Johannes Gutenberg University in Mainz, 2000.
Medical Director
Successful post as medical director of the Neurosurgical Clinic at the Klinikum Stuttgart, one of the largest neurosurgical clinics in Germany.
Founding of NeuroChirurgicum
Foundation of the "NeuroChirurgicum" centre in Stuttgart, with a focus on endoscopic and minimally invasive neurosurgery.
Foundation of ENDOMIN College
Founding of ENDOMIN College together with companion and friend Professor Robert Reisch.
After six years of parallel work in two countries, all Professor Hopf's professional activities were transferred to Switzerland where he took up a leading position at the Centre for Neurosurgery at the Hirslanden Clinic in Zurich.
Close cooperation with the newly-founded Swiss Neuro Radiosurgery Center (SNRC) and the Swiss Neuro Radiology Institute (SNRI) in Zurich.


Endoscopic ventriculostomy

Endoscopic cyst fenestration

Endoscopic-assisted operation of skull-base epidermoid

Interview on Minimally invasive neurosurgery in "Lieder-Liebe-Leben"

Health seminar on the subject of "Living with cancer".

Selected publications:

Hopf NJ, Bremm J, Bohl J, Perneczky A (1994)

Image analysis of proliferating cells in tumors of the human nervous system: An immunohistological study using the monoclonal antibody Ki-67.

Neurosurgery 35: 917-923Hopf NJ, Füllbier L (2010)

Hopf NJ, Perneczky A (1998)

Endoscopic neurosurgery and endoscope-assisted microneurosurgery for the treatment of intracranial cysts.

Neurosurgery 43: 1330-1337

Hopf NJ, Grunert P, Fries G, Resch KDM, Perneczky A (1999)

Endoscopic third ventriculostomy: Outcome analysis of 100 consecutive procedures. Neurosurgery 44: 795-806

Hopf NJ, Grunert P, Darabi K, Busert C, Perneczky A (1999)

Frameless neuronavigation applied to endoscopic neurosurgery.

Minim Invas Neurosurg 42: 187-193

Hopf NJ (1999)

Endoscopic neurosurgery „around the corner“ with a rigid endoscope.

Minim Invas Neurosurg 42: 27-31

Kanner A, Hopf NJ, Grunert P (2000)

The „optimal“ burr hole position for endoscopic third ventriculostomy: results from 31 stereotactically guided procedures.

Minim Invas Neurosurg 43: 187-189

Demuth T, Hopf NJ, Kempski O, Sauner D, Herr M, Giese A, Perneczky A (2001)

Migration activity of human glioma cell lines in vitro assessed by continuous single cell observation.

Clin Exp Metastas 18: 589-597

Koch D, Grunert P, Filippi R, Hopf NJ (2002)

Re-ventriculostomy for treatment of obstructive hydrocephalus in cases of stoma dysfunction.

Minim Invasiv Neurosurg 45: 158-163

Hopf NJ, Stadie A, Reisch R (2009)

Management of bilateral middle cerebral artery aneurysms via a Unilateral Supraorbital

Key-Hole Craniotomy

Minim Invasiv Neurosurg 52: 126-131

Reisch R, Stadie A, Kockro R, Gawish I, Schwandt E, Hopf NJ (2009)

Supraorbital subfrontal key-hole approach for surgical treatment of temporomesial lesions of the dominant hemisphere

Minim Invasiv Neurosurg 52: 163-169

Hopf NJ, Füllbier L (2010)

Minimally invasive neurosurgery for vascular lesions.

Neurosurg Clin N Am 21(4): 673-689

Fischer G, Stadie A, Reisch R, Hopf NJ, Fries G, Böcher-Schwarz H, van Lindert E, Ungersböck K, Knosp E, Oertel J, Perneczky A (2011)

The keyhole concept in aneurysm surgery: results of the past 20 years.

Neurosurgery 68 (1 Suppl Operative):45-51; discussion 51.

Coburger J, Musahl C, Henkes H, Horvath-Rizea D, Bittl M, Weissbach C, Hopf N (2012)

Comparison of navigated transcranial magnetic stimulation and functional magnetic resonance imaging for preoperative mapping in rolandic tumor surgery

Neurosurg Rev 36: 65-75, discussion 75-76

Coburger J, Karhu J, Bittl M, Hopf NJ (2012)

First preoperative functional mapping via navigated transcranial magnetic stimulation in a 3-year-old boy.

J Neurosurg Pediatr 9 (6): 660-664

Reisch R, Stadie A, Kockro RA, Hopf N (2012)

The keyhole concept in Neurosurgery.

World Neurosurg 79 (2 Suppl); p. S17.e9-13 /201302/

Kurucz P, Baksa G, Patonay L, Hopf NJ (2013)

Endoscopic anatomical study of the arachnoid architecture on the base of the skull: Part I: The anterior and middle cranial fossa

Innovative Neurosurgery 1(1): 55-66

Kurucz P, Baksa G, Patonay L, Hopf NJ (2013)

Endoscopic anatomical study of the arachnoid architecture on the base of the skull: Part II: Level of the tentorium, posterior cranial fossa and the craniovertebral junction

Innovative Neurosurgery 1(2): 91-108

Hopf NJ, Kurucz P, Reisch R (2013)

Three-dimensional HD endoscopy – first experiences with the Einstein Vision system in neurosurgery

Innovative Neurosurgery 1(2): 125-131

Renovanz M, Gutenberg A, Haug M, Strittmacher E, Mazur J, Nadji-Ohl M, Giese A, Hopf N (2013)

Postsurgical screening for psychological disorders in neurooncological patients

Acta neurochirurgica; VOL: 155 (12); p. 2255-61 /201312/

Renovanz M, Hickmann A-K, Henkel C, Nadji-Ohl M, Hopf NJ (2014)

Navigated versus non-navigated intraoperative ultrasound: is there any impact on the extend of resection of high-grade gliomas? A retrospective clinical analysis.

J Neurol surg A 75: 224-230

Thaher F, Kurucz P, Fuellbier L, Bittl M, Hopf NJ (2014)

Endoscopic surgery for tumors of the pineal region via a paramedian infratentorial supracerebellar keyhole approach (PISKA)

Neurosurgical Review 37: 677-684

Hickmann A; Nadji-Ohl M; Hopf NJ (2014)

Feasibility of fluorescence-guided resection of recurrent gliomas using five-aminolevulinic acid: retrospective analysis of surgical and neurological outcome in 58 patients.

Journal of neuro-oncology /20150104/

Reisch R; Fischer G; Stadie A; Kockro R; Cesnulis E; Hopf N (2014)

The Supraorbital Endoscopic Approach for Aneurysms.

World neurosurgery; VOL: 82 (6S); p. S130-S137

Renovanz M; Hickmann AK; Gutenberg A; Bittl M; Hopf NJ (2015)

Does size matter? Minimally invasive approach in pediatric neurosurgery–a review of 125 minimally invasive surgeries in children: clinical history and operative results. Childs Nerv Syst. 2015;31(5):665-74

Thaher F, Hopf N, Hickmann AK, Kurucz P, Henkes H, Feigl G (2015)

Supraorbital keyhole approach to the skull base: evaluation of complications related to CSF fistulas and opened frontal sinus.

J Neurol Surg A Cent EUR Neurosurg; 76(6): 433-7

Hickmann A-K; Nadji-Ohl M; Haug M; Hopf NJ; Ganslandt O; Giese A; Renovanz M (2016)

Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients

Acta Neurochir; DOI 10.1007/s00701-016-2844-y

Lan Q, Sughrue M, Hopf NJ, Mori K, Park J, Andrade-Barazarte H, Balamurugan M, Cenzato M, Broggi G, Kang D, Kikuta K, Zhao H, Irie S, Li Y, Liew BS, Kato Y (2019)

International expert consensus statement about methods and indications for keyhole microneurosurgery from International Society on Minimally Invasive Neurosurgery.

Neurosurg Rev; 21, DOI 10.1007/s10143-019-01188-z

Bücher (Herausgeber)

Hopf NJ, Tonn J (Hrsg)

Neurochirurgische Akademie: Vaskuläre Neurochirurgie, Funktionelle Neurochirurgie

Georg Thieme Verlag Stuttgart-New York, 2011

Reisch R, Hopf N (Hrsg)

Transcranial Endoscope-Assisted Microsurgery: A practical Atlas

Aesculap AG

Ausgewählte Buchbeiträge

Hopf NJ, Resch KDM, Ringel K, Perneczky A:

Endoscopic Management of Intracranial Arachnoid Cysts.

In: Hellwig D, Bauer LB (edts): Minimally Invasive Techniques for Neurosurgery, Springer Verlag Berlin Heidelberg New York, pp: 111-119, 1998

Hopf NJ, Füllbier L:

Minimally invasive Neurosurgery for vascular lesions

In: Sughrue, Teo (Edts.): Neurosurgery Clinics of North America: Minimally Invasive Intracranial Surgery, Elsevier Verlag New York, 2010

Hopf NJ:

Nichtrupturierte Aneurysmen: Zeitbombe im Kopf

In: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Steiger H-J, Hopf NJ:

Arteriovenöse Malformationen: Klassifikation

in: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Musahl C, Schul C, Hopf NJ:

Intraoperative Indozyaningrün (ICG)-Fluoreszenzangiographie „IR 800“ der Firma ZEISS

in: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Hopf NJ, Musahl C, Henkes H:

Carotid Cavernous Fistulas: Part I: Presentation and Features

in: Spetzler, Kalani, Nakaji (Hrsg): Neurovascular Surgery, 2nd Edition,

Thieme Verlag Stuttgart – New York, 2015

Musahl C, Weissbach C, Hopf NJ:


in: Spetzler, Kalani, Nakaji (Hrsg): Neurovascular Surgery, 2nd Edition,

Thieme Verlag Stuttgart – New York, 2015

Musahl C and Hopf NJ:

Neuromonitoring for arteriovenous malformation surgery

in: Spetzler RF, Kondziolka DS, Higashida RT, Kalani MYS: Comprehensive Management of Arteriovenous Malformations of the Brain and Spine

Cambridge University Press, 2015

Hopf NJ, Reisch R, P Kurucz:

Neurovascular Compression Syndromes

in: König A, Spetzger U: Skull Base Surgery – Schädelbasischirurgie

Springer International Publishing, 2018

DOI: 10.1007/978-3-319-64018-1

Hopf NJ and Gardner PA:

Intracranial Aneurysms

in: Evans JJ, Kenning TJ, Farrell C, Kshettry V (Hrsg): Endoscopic and Keyhole Cranial Base Surgery

Springer International Publishing, 2019

DOI: 10.1007/978-3-319-64379-3

Hopf N, Reisch R:

Skull Base Approaches: Supraorbital

in: Raabe A (Hrsg): The Craniotomy Atlas

Thieme Verlag Stuttgart, 2019

Hopf NJ.

Tumors of the anterolateral skull base: anterior clinoid: Perspective

in: Jean W (Hrsg): Skull base surgery: strategies

Thieme Verlag New York-Stuttgart-Delhi-Rio de Janeiro, 2019DOI: 10.1017/S0022215119001221

Musahl C, Hopf NJ:

Neuromonitoring for brainstem surgery

in: Spetzler, Kalani, Lawton (Hrsg): Surgery of the brainstem

Thieme Verlag New York-Stuttgart-Delhi-Rio de Janeiro, 2020

DOI: 10.1055/b-006-164726